Endocrine Abstracts

Case report: A 9-year-old girl of mixed ethnic origin presented with symptomatic hypercalcaemia with a 3-month history of weight loss and lethargy. Autoimmune hypothyroidism had been diagnosed 10 months previously. Serum vitamin D concentration (11 nmol/l) was low and cholecalciferol 20 000 units daily for 7 days followed by 800 units daily was commenced. One month later, her symptoms worsened and she had developed anaemia and renal impairment. Hypercalcaemia was noted (Corr C...

Cushing’s disease (CD) is rare in childhood. There are well described cohorts of patients with classical features. However, given the rarity of CD, we feel it is valuable to share lessons learnt from the treatment of atypical cases.Case 1: Thirteen-year-old male presented with Cushingoid features. Investigation indicated ACTH excess: 0900 h ACTH 20 pmol/l per cortisol 798 nmol/l; midnight cortisol 724 nmol/l. MRI demonstrated a pituitary macroadenom...